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Article

Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chain.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2005

Bill Jerome R, Mack Douglas G, Falta Michael T, Maier Lisa A, Sullivan Andrew K, Joslin Fenneke G, Martin Allison K, Freed Brian M, Kotzin Brian L, Fontenot Andrew P

Abstract excerpt

Chronic beryllium disease (CBD) is characterized by a CD4+ T cell alveolitis and granulomatous inflammation in the lung. Genetic susceptibility to this disease has been linked with HLA-DP alleles, particularly those possessing a glutamic acid at position 69 (Glu69) of the beta-chain. However, 15% of CBD patients do not possess a Glu69-containing HLA-DP allele, suggesting that other MHC class II alleles may be...

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Share to Antigen Presentation
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16272364
DOI: 10.4049/jimmunol.175.10.7029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chain.PMID 16272364Read ↗

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