Article
Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 1993
Bourgeois S, Gruol D J, Newby R F, Rajah F M
Abstract excerpt
A variant, MS23, of murine thymoma W7 cells, previously selected for its resistance to low concentrations of dexamethasone, is cross-resistant to unrelated drugs such as puromycin and colchicine. We report here that transcription of the mouse mdr1 gene is activated and P-glycoprotein is expressed...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Apoptosis
- Blotting, Southern
- Carrier Proteins
- Colchicine
- Dexamethasone
- Dose-Response Relationship, Drug
- Drug Resistance
- Flow Cytometry
- Gene Amplification
- Gene Expression Regulation, Neoplastic
- Genetic Variation
- Membrane Glycoproteins
- Mice
- Mice, Inbred BALB C
- Neoplasms, Experimental
- Phenotype