Article
Glucocorticoid-receptor-gene defects and resistance to glucocorticoid-induced apoptosis in human leukemic cell lines.
International journal of cancer - 27 Nov 1996
Hala M, Hartmann B L, Böck G, Geley S, Kofler R
Abstract excerpt
The application of glucocorticoids (GC3) in human leukemia is based on apoptosis induction but is often hampered by GC resistance. To delineate resistance mechanisms, we examined 5 GC-resistant leukemic cell lines, termed CEM-C7.R1-R5, isolated from the GC-sensitive human acute-T-cell-leukemic li...
Topics
- Alleles
- Amino Acid Sequence
- Apoptosis
- Drug Resistance, Neoplasm
- Gene Expression Regulation, Neoplastic
- Glucocorticoids
- Humans
- Leukemia
- Molecular Sequence Data
- Mutation
- Receptors, Glucocorticoid
- Tumor Cells, Cultured