Article
Phenotypical alterations induced by glucocorticoids resistance in RPMI 8226 human myeloma cells.
Leukemia research - 1 Mar 2004
Genty Vincent, Dine Gérard, Dufer Jean
Abstract excerpt
Resistance to glucocorticoids (GCs) frequently appears during treatment of hematological malignancies. This study investigates the phenotypical alterations observed in human myeloma cell sublines resistant to glucocorticoids. Using the RPMI8226 cell line, the cytotoxic efficiencies of four glucocorticoids, and the phenotypes of isolated resistant sublines were analyzed. Methyl-prednisolone and dexamethasone...
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