Article
Recessive mutations in a common pathway block thymocyte apoptosis induced by multiple signals.
The Journal of cell biology - 1 Dec 1994
Flomerfelt F A, Miesfeld R L
Abstract excerpt
The glucocorticoid receptor (GR) is a ligand-regulated transcription factor that controls genes necessary to initiate glucocorticoid-induced thymocyte apoptosis. We have performed a genetic analysis of thymocyte cell death by isolating and characterizing a panel of GR+ dexamethasone-resistant mut...
Topics
- Animals
- Apoptosis
- Calcimycin
- Cells, Cultured
- Cyclic AMP
- Dexamethasone
- Gamma Rays
- Gene Dosage
- Gene Expression
- Genetic Complementation Test
- Hydrogen Peroxide
- Mice
- Models, Biological
- Mutation
- Phenotype
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- Receptors, Glucocorticoid