Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recessive mutations in a common pathway block thymocyte apoptosis induced by multiple signals.

The Journal of cell biology - 1 Dec 1994

Flomerfelt F A, Miesfeld R L

Abstract excerpt

The glucocorticoid receptor (GR) is a ligand-regulated transcription factor that controls genes necessary to initiate glucocorticoid-induced thymocyte apoptosis. We have performed a genetic analysis of thymocyte cell death by isolating and characterizing a panel of GR+ dexamethasone-resistant mutants of the murine WEHI7.2 thymocyte cell line. These apoptosis-defective (Apt-) mutants were used to identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Models, Biological
Share to Mutation
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Genetic Complementation Test

Share to Phenotype

Share to Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7798323
DOI: 10.1083/jcb.127.6.1729
PMCID: PMC2120285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recessive mutations in a common pathway block thymocyte apoptosis induced by multiple signals.PMID 7798323Read ↗

Evidence that glucocorticoid- and cyclic AMP-induced apoptotic pathways in lymphocytes share distal events.Semantic proximity Read ↗

Glucocorticoid-induced apoptosis of healthy and malignant lymphocytes.Semantic proximity Read ↗

Cytotoxic T lymphocytes and glucocorticoids activate an endogenous suicide process in target cells.Semantic proximity Read ↗

Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance.Semantic proximity Read ↗

p53 is required for radiation-induced apoptosis in mouse thymocytes.Semantic proximity Read ↗

Modulations of glucocorticoid-induced apoptosis linked to the p53 deletion and to the apoptosis susceptibility gene Rapop1 (Radiation-induced apoptosis 1).Semantic proximity Read ↗

Stepping stones in the path of glucocorticoid-driven apoptosis of lymphoid cellsSemantic proximity Read ↗

BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosisSemantic proximity Read ↗

Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells.Semantic proximity Read ↗

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas.Semantic proximity Read ↗

A recessive mutant of the U937 cell line acquired resistance to anti-Fas and anti-p55 tumor necrosis factor receptor antibody-induced apoptosis.Semantic proximity Read ↗

Glucocorticoid-induced apoptosis and glucocorticoid resistance in acute lymphoblastic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.