Article
Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2).
Nature - 1 Jan 2000
Peterson A, Seed B
Abstract excerpt
The human T cell erythrocyte receptor (CD2 antigen) allows thymocytes and mature T cells to adhere to thymic epithelium and target cells through a cell surface protein, LFA-3 (refs 1-6). Monoclonal antibodies recognizing CD2 can either block adhesion or, in certain combinations, induce an antigen-independent T cell activation. We have identified the binding sites for 16 monoclonal antibodies against CD2 by a...
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