Ligand-induced conformational change within the CD2 ectodomain accompanies receptor clustering: implication for molecular lattice formation.

doi:10.1006/jmbi.1996.0570

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Article

Ligand-induced conformational change within the CD2 ectodomain accompanies receptor clustering: implication for molecular lattice formation.

Journal of molecular biology - 25 Oct 1996

Li J, Smolyar A, Sunder-Plassmann R, Reinherz E L

Abstract excerpt

CD2 mediates interaction between T cells and their cognate partners through its CD58-binding membrane-distal adhesion domain (D1) facilitating T cell receptor (TCR) triggering. A neoepitope defined by anti-CD2R monoclonal antibodies (mAbs) has suggested structural alteration within the CD2 ectodo...

Topics

CD2 Antigens
Cell Adhesion
Cell Line
Epitope Mapping
Humans
Ligands
Mutation
Protein Conformation
Receptors, Immunologic
T-Lymphocytes

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