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Article

Molecular basis of the dual functions of 2B4 (CD244).

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2008

Chlewicki Lukasz K, Velikovsky C Alejandro, Balakrishnan Vamsi, Mariuzza Roy A, Kumar Vinay

Abstract excerpt

2B4 belongs to the CD2 family of molecules and is expressed on all NK, gammadelta, and memory CD8(+) (alphabeta) T cells. The murine NK receptor 2B4 exhibits both inhibitory and activating functions, whereas human 2B4 has been reported to be an activating molecule. How murine 2B4 can act both as an activating and inhibitory receptor and what distinguishes its function from human 2B4 have remained largely unknown....

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Identifiers

PMID: 18523281
DOI: 10.4049/jimmunol.180.12.8159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular basis of the dual functions of 2B4 (CD244).PMID 18523281Read ↗

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