CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells.

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Article

CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells.

Blood - 15 Feb 1997

Teh S J, Killeen N, Tarakhovsky A, Littman D R, Teh H S

Abstract excerpt

The CD2 glycoprotein has been implicated in both positive and negative regulation of T-cell mitogenesis. To study the involvement of CD2 in T-lymphocyte development and immune responses, we have analyzed two lines of CD2-null mice, each expressing a distinct class I major histocompatibility compl...

Topics

Animals
Antigens
Antigens, CD
CD2 Antigens
CD8-Positive T-Lymphocytes
Clonal Deletion
Crosses, Genetic
Female
Genotype
H-2 Antigens
H-Y Antigen
Interferon-gamma
Lymphocyte Activation
Membrane Glycoproteins
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Knockout

Source

Open in PubMed

Identifiers

PMID: 9028954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9028954-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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