Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells.

Blood - 15 Feb 1997

Teh S J, Killeen N, Tarakhovsky A, Littman D R, Teh H S

Abstract excerpt

The CD2 glycoprotein has been implicated in both positive and negative regulation of T-cell mitogenesis. To study the involvement of CD2 in T-lymphocyte development and immune responses, we have analyzed two lines of CD2-null mice, each expressing a distinct class I major histocompatibility complex (MHC)-restricted T-cell receptor (TCR). In both situations, the absence of CD2 appeared to promote the positive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Crosses, Genetic
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lymphocyte Activation

Share to Membrane Glycoproteins

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Source

Identifiers

PMID: 9028954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells.PMID 9028954Read ↗

Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage.Semantic proximity Read ↗

An anti-CD2 monoclonal antibody that both inhibits and stimulates T cell activation recognizes a subregion of CD2 distinct from known ligand-binding sites.Semantic proximity Read ↗

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient MiceSemantic proximity Read ↗

Analysis of CD2 and TCR-beta gene expression in Jurkat cell mutants suggests a cis regulation of gene transcription.Semantic proximity Read ↗

Negative selection of thymocytes expressing the D10 TCR.Semantic proximity Read ↗

Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway.Semantic proximity Read ↗

CD2 expression on murine intestinal intraepithelial lymphocytes is bimodal and defines proliferative capacity.Semantic proximity Read ↗

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function.Semantic proximity Read ↗

Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene.Semantic proximity Read ↗

Positive selecting cell type determines the phenotype of MHC class Ib-restricted CD8+ T cells.Semantic proximity Read ↗

CD8 lineage commitment in the absence of CD8.Semantic proximity Read ↗

Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.