Article
Differential interaction of the CD2 extracellular and intracellular domains with the tyrosine phosphatase CD45 and the zeta chain of the TCR/CD3/zeta complex.
European journal of immunology - 1 Dec 1996
Verhagen A M, Schraven B, Wild M, Wallich R, Meuer S C
Abstract excerpt
T cell activation via CD2 requires interaction of CD2 with several signaling molecules. To investigate the structural requirements for an association of CD2 with the tyrosine phosphatase CD45 and the zeta chain of the T cell receptor (TCR)/CD3/zeta complex, we have expressed in mouse EL4 T cells...
Topics
- Animals
- CD2 Antigens
- Cytoplasm
- Humans
- Leukocyte Common Antigens
- Lymphoma, T-Cell
- Membrane Proteins
- Mice
- Mutation
- Protein Binding
- Protein Conformation
- Receptor-CD3 Complex, Antigen, T-Cell
- Receptors, Antigen, T-Cell
- Recombinant Fusion Proteins
- Tumor Cells, Cultured