Article
Expression of the CD2 activation epitope T11-3 (CD2R) on T cells in rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and Lyme disease: phenotypic and functional analysis.
Scandinavian journal of immunology - 1 Sept 1991
Potocnik A J, Menninger H, Yang S Y, Pirner K, Krause A, Burmester G R, Bröker B M, Hept P, Weseloh G, Michels H
Abstract excerpt
CD2R is an activation-associated epitope unmasked by a conformational change of the CD2 cell-surface glycoprotein. In spite of elaborate studies on the role of CD2 and CD2R in adhesion and stimulation of T cells in vitro, no instances of CD2R expression in vivo were known to date. We report high levels of CD2R observed on blood and synovial fluid T cells in rheumatoid arthritis and on peripheral blood T cells in...
Topics
- Antigens, Differentiation, T-Lymphocyte
- Arthritis
- Arthritis, Juvenile
- Arthritis, Rheumatoid
- CD2 Antigens
- Epitopes
- Humans
- Lupus Erythematosus, Systemic
- Lyme Disease