Article
Monoclonal antibody FMC7 detects a conformational epitope on the CD20 molecule: evidence from phenotyping after rituxan therapy and transfectant cell analyses.
Cytometry - 15 Apr 2001
Serke S, Schwaner I, Yordanova M, Szczepek A, Huhn D
Abstract excerpt
Numerous studies have reported that monoclonal antibody (mAb) FMC7 detects an antigen present on only a subset of circulating B lymphocytes. In particular, this mAb may distinguish typical B-cell chronic lymphocytic leukemia (FMC7 negative) from other types of B-cell non-Hodgkin lymphoma (B-NHL; FMC7 positive). We treated patients with B-NHL with Rituxan, a chimeric CD20 mAb, and observed abrogation of staining...
Topics
- Antibodies, Blocking
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Antigen-Antibody Reactions
- Antigens, CD20
- Antigens, Differentiation, B-Lymphocyte
- Antigens, Neoplasm
- Antineoplastic Agents
- Electroporation
- Epitopes
- Flow Cytometry
- Glycoproteins
- Humans