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Article

Alteration in the retinoblastoma gene associated with immortalization of human fibroblasts treated with 60Co gamma rays.

Journal of cancer research and clinical oncology - 1 Jan 1993

Endo A, Kano Y, Mihara K, Orita K, Namba M

Abstract excerpt

Genetic analysis was carried out in human fibroblasts (KMST-6) immortalized by treatment with 60Co gamma rays in order to determine if any genetic change was involved in the immortal transformation of human cells. Analysis by restriction fragment length polymorphism revealed an alteration in chro...

Topics

Cell Transformation, Neoplastic
Cells, Cultured
Chromosomes, Human, Pair 13
Cobalt Radioisotopes
Fibroblasts
Gene Expression Regulation, Neoplastic
Genes, Retinoblastoma
Humans
Mutation
Phosphorylation
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precipitin Tests

Retinoblastoma Protein

Source

Identifiers

PMID: 8100822
DOI: 10.1007/BF01686461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8100822-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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