Article
Malignant transformation of human diploid fibroblasts and suppression of their anchorage independence by introduction of chromosome 13.
Genes, chromosomes & cancer - 1 Sept 1999
Oka K, Tomonaga Y, Nakazawa T, Ge H Y, Bengtsson U, Stanbridge E J, Yoshioka N, Li Q, Hakura A, Yutsudo M
Abstract excerpt
Isolation of cell lines that display various degrees of transformed phenotypes may be very useful to clarify multistep mechanisms of oncogenesis, but malignant transformation of human diploid fibroblasts in culture is a very rare event. We attempted to isolate variously transformed cell lines from human diploid fibroblasts (RB) of a patient with hereditary retinoblastoma. The RB cells exhibited normal karyotypes...
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