The retinoblastoma susceptibility gene product regulates Myc-mediated transcription.

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Article

The retinoblastoma susceptibility gene product regulates Myc-mediated transcription.

Oncogene - 19 Jan 1995

Adnane J, Robbins P D

Abstract excerpt

The protein product of the retinoblastoma tumor suppressor gene (RB) has been demonstrated to bind c-Myc protein (Myc) in vitro. To determine whether RB regulates Myc transcriptional activity in vivo, GAL4-Myc chimeric expression plasmids were generated and cotransfected with a RB expression plas...

Topics

Antigens, Polyomavirus Transforming
DNA-Binding Proteins
Fungal Proteins
Gene Expression Regulation
Genes, Retinoblastoma
Herpes Simplex Virus Protein Vmw65
Humans
Mutation
Proto-Oncogene Proteins c-myc
Recombinant Proteins
Retinoblastoma Protein
Saccharomyces cerevisiae Proteins
Transcription Factors
Transcription, Genetic
Transfection
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7838535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7838535-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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