Article
p53 gene mutations and abnormal retinoblastoma protein in radiation-induced human sarcomas.
Cancer research - 1 Dec 1991
Brachman D G, Hallahan D E, Beckett M A, Yandell D W, Weichselbaum R R
Abstract excerpt
The potentially carcinogenic effect of therapeutic irradiation has been recognized for many years. Second malignancies, usually sarcomas, are known to arise within or at the edge of radiation fields after a period of several years after the initial radiation exposure. We analyzed tumor cells derived from seven radiation-induced tumors for abnormalities in tumor suppressor genes p53 and retinoblastoma at the DNA...
Topics
- Amino Acid Sequence
- Exons
- Genes, Retinoblastoma
- Genes, p53
- Molecular Sequence Data
- Mutation
- Neoplasms, Radiation-Induced
- Polymerase Chain Reaction
- Retinoblastoma Protein
- Sarcoma
- Tumor Cells, Cultured