Article
Oncosuppressor genes: mechanisms of inactivation for the retinoblastoma gene and p53.
Bollettino della Societa italiana di biologia sperimentale - 1 Dec 1993
Clerico L, Mancuso T, Noonan D, Albini A
Abstract excerpt
Mutations that affect oncosuppressor genes contribute to transformed phenotype. The recessive characteristics of these genes require mutations on both alleles. For this reason alterations of the oncosuppressor genes can be transmitted with the germ line. In this review we focus on mechanisms of inactivation of the retinoblastoma gene and p53. The products of these genes are nuclear phosphoproteins involved in...
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