Oncosuppressor genes: mechanisms of inactivation for the retinoblastoma gene and p53.

Article

Oncosuppressor genes: mechanisms of inactivation for the retinoblastoma gene and p53.

Bollettino della Societa italiana di biologia sperimentale - 1 Dec 1993

Clerico L, Mancuso T, Noonan D, Albini A

Abstract excerpt

Mutations that affect oncosuppressor genes contribute to transformed phenotype. The recessive characteristics of these genes require mutations on both alleles. For this reason alterations of the oncosuppressor genes can be transmitted with the germ line. In this review we focus on mechanisms of i...

Topics

Animals
Genes, Retinoblastoma
Genes, p53
Humans
Mutation

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