Article
The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.
The EMBO journal - 1 Apr 1990
Hu Q J, Dyson N, Harlow E
Abstract excerpt
The protein product of the retinoblastoma (RB) gene is thought to function in a pathway that restricts cell proliferation. Recently, transforming proteins from three different classes of DNA tumor viruses have been shown to form complexes with the RB protein. Genetic studies suggest that these in...
Topics
- Adenovirus Early Proteins
- Base Sequence
- Binding Sites
- Chromosome Deletion
- DNA-Binding Proteins
- Eye Neoplasms
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Oncogene Proteins, Viral
- Phosphoproteins
- Polymerase Chain Reaction
- Protein Binding
- Protein Biosynthesis
- Retinoblastoma
- Retinoblastoma Protein
- Suppression, Genetic