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Article

Molecular genetic changes in human epithelial ovarian malignancies.

Gynecologic oncology - 1 Nov 1992

Gallion H H, Powell D E, Morrow J K, Pieretti M, Case E, Turker M S, DePriest P D, Hunter J E, van Nagell J R

Abstract excerpt

The frequent finding of loss of heterozygosity (LOH) for a specific chromosomal marker in tumor DNA compared to normal DNA suggests the presence of a closely linked tumor-suppressor gene. Using Southern blot analysis, 34 primary ovarian epithelial tumors were examined for the presence of tumor-specific allelic losses, using six probes for chromosomes 6q, 11p, 13q, 16q, and 17p. A high incidence of LOH was...

Topics

Alleles
Blotting, Southern
Carcinoma
DNA Probes
DNA, Neoplasm
Female
Gene Deletion
Genes, Tumor Suppressor
Heterozygote
Humans
Neoplasm Staging
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1468689
DOI: 10.1016/0090-8258(92)90096-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1468689-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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