Article
The immunogenic properties of drug-resistant murine tumor cells do not correlate with expression of the MDR phenotype.
Cancer immunology, immunotherapy : CII - 1 Jun 1993
Killion J J, Radinsky R, Dong Z, Fishbeck R, Whitworth P, Fidler I J
Abstract excerpt
Alterations in the immunogenic properties of tumor cells frequently accompany selection for multiple-drug-resistant (MDR) variants. Therefore, studies were performed to examine the hypothesis that overexpression of membrane P-glycoprotein, commonly observed in MDR tumor cells, is associated with enhanced immunogenic properties. Immunogenicity was determined by (a) the ability of drug-sensitive parental UV2237M...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
