Article
The immunogenic properties of drug-resistant murine tumor cells do not correlate with expression of the MDR phenotype.
Cancer immunology, immunotherapy : CII - 1 Jun 1993
Killion J J, Radinsky R, Dong Z, Fishbeck R, Whitworth P, Fidler I J
Abstract excerpt
Alterations in the immunogenic properties of tumor cells frequently accompany selection for multiple-drug-resistant (MDR) variants. Therefore, studies were performed to examine the hypothesis that overexpression of membrane P-glycoprotein, commonly observed in MDR tumor cells, is associated with...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adenocarcinoma
- Animals
- Carrier Proteins
- Doxorubicin
- Drug Resistance
- Fibrosarcoma
- Membrane Glycoproteins
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Nude
- Ouabain
- Phenotype
- Sarcoma, Experimental