Article
Effect of recombinant fibroblast interferon and recombinant immune interferon on growth and the antigenic phenotype of multidrug-resistant human glioblastoma multiforme cells.
Journal of the National Cancer Institute - 18 Sept 1991
Reddy P G, Graham G M, Datta S, Guarini L, Moulton T A, Jiang H P, Gottesman M M, Ferrone S, Fisher P B
Abstract excerpt
To study the effect of drug resistance on the response of stage IV astrocytomas to interferon, a human glioblastoma multiforme cell line, GBM-18, was transfected with an expression-vector plasmid containing a human multidrug resistance (MDR) gene (pHaMDR1/A), and clones surviving in colchicine were isolated. GBM-18 multidrug-resistant subclones displayed cross-resistance to other chemotherapeutic agents,...
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