Sensitivity of drug-resistant human ovarian tumor cell lines to combined effects of tumor necrosis factor (TNF-alpha) and doxorubicin: failure of the combination to modulate the MDR phenotype.

doi:10.1006/gyno.1993.1036

Article

Sensitivity of drug-resistant human ovarian tumor cell lines to combined effects of tumor necrosis factor (TNF-alpha) and doxorubicin: failure of the combination to modulate the MDR phenotype.

Gynecologic oncology - 1 Feb 1993

Safrit J T, Berek J S, Bonavida B

Abstract excerpt

We have examined four human ovarian tumor lines (A2780, AD10, OVC-8, and SKOV-3) selected for their sensitivity and/or resistance to the recombinant human tumor necrosis factor alpha (TNF-alpha) and the chemotherapeutic drug doxorubicin (DOXO). The tumor lines were either sensitive to both agents...

Topics

Doxorubicin
Drug Resistance
Drug Synergism
Female
Humans
Ovarian Neoplasms
Phenotype
RNA, Messenger
RNA, Neoplasm
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha

Sensitivity of drug-resistant human ovarian tumor cell lines to combined effects of tumor necrosis factor (TNF-alpha) and doxorubicin: failure of the combination to modulate the MDR phenotype.

Abstract excerpt

Topics

Discuss the evidence