Article
Differential expression of steroid receptors, hsp27, and pS2 in a series of drug resistant human breast tumor cell lines derived following exposure to antitumor drugs or to fractionated X-irradiation.
Breast cancer research and treatment - 1 Jan 1993
Whelan R D, Hill B T
Abstract excerpt
This study examined whether levels of estrogen receptor (ER), progesterone receptor (PR), and expression of estrogen regulated pS2 and/or heat shock protein (hsp) 27 were associated with drug resistance in a series of MCF-7 sublines expressing modest (i.e. 3- to 14-fold), yet clinically relevant,...
Topics
- Antineoplastic Agents
- Biomarkers, Tumor
- Breast Neoplasms
- Doxorubicin
- Drug Resistance
- Estrogen Antagonists
- Estrogens
- Heat-Shock Proteins
- Humans
- Neoplasm Proteins
- Phenotype
- Proteins
- Receptors, Estrogen
- Receptors, Progesterone
- Trefoil Factor-1
- Tumor Cells, Cultured
- Tumor Suppressor Proteins
- Vincristine