Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.

Biochemistry - 10 Jan 1995

Tang-Wai D F, Kajiji S, DiCapua F, de Graaf D, Roninson I B, Gros P

Abstract excerpt

Possible functional differences between P-glycoproteins (P-gps) encoded by the human MDR1 and mouse mdr1 and mdr3 genes with respect to drug resistance profiles and sensitivity to known modulators have been investigated. For this, the three genes were introduced and overexpressed in the same cell...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
CHO Cells
Cell Survival
Clone Cells
Cricetinae
Cricetulus
Drug Resistance
Humans
Mice
Models, Molecular
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Species Specificity

Transfection

Vinblastine

Source

Identifiers

PMID: 7819214
DOI: 10.1021/bi00001a005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7819214-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.PMID 7819214Read ↗

Functional analysis of chimeric proteins constructed by exchanging homologous domains of two P-glycoproteins conferring distinct drug resistance profiles.Semantic proximity Read ↗

Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening.Semantic proximity Read ↗

[Multiple drug resistance].Semantic proximity Read ↗

Evaluating limited specificity of drug pumps reduced relative resistance in human MDR phenotypes.Semantic proximity Read ↗

Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters.Semantic proximity Read ↗

Molecular Targets in Oncology: Implications of the Multidrug Resistance GeneSemantic proximity Read ↗

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance.Semantic proximity Read ↗

Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein.Semantic proximity Read ↗

Genetic aspects of multidrug resistance.Semantic proximity Read ↗

Diversity of multidrug resistance in mammalian cells.Semantic proximity Read ↗

Multidrug resistance and the role of P-glycoprotein knockout mice.Semantic proximity Read ↗

New Insight into P-Glycoprotein as a Drug TargetSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.