Article
Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening.
Cancer research - 1 Jun 1992
Wu L, Smythe A M, Stinson S F, Mullendore L A, Monks A, Scudiero D A, Paull K D, Koutsoukos A D, Rubinstein L V, Boyd M R
Abstract excerpt
Disease-oriented panels of human tumor cell lines used by the National Cancer Institute for large-scale in vitro anticancer drug screening were evaluated for multidrug-resistant phenotype at the functional (in vitro drug sensitivity) and molecular levels. The cell line panels manifested a broad range of sensitivities to drugs typically associated with multidrug resistance (MDR) as well as to drugs not associated...
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