Article
Multidrug-resistant phenotype of disease-oriented panels of human tumor cell lines used for anticancer drug screening.
Cancer research - 1 Jun 1992
Wu L, Smythe A M, Stinson S F, Mullendore L A, Monks A, Scudiero D A, Paull K D, Koutsoukos A D, Rubinstein L V, Boyd M R
Abstract excerpt
Disease-oriented panels of human tumor cell lines used by the National Cancer Institute for large-scale in vitro anticancer drug screening were evaluated for multidrug-resistant phenotype at the functional (in vitro drug sensitivity) and molecular levels. The cell line panels manifested a broad r...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antibodies, Monoclonal
- Antineoplastic Agents
- Base Sequence
- Cell Line
- DNA, Neoplasm
- Drug Resistance
- Drug Screening Assays, Antitumor
- Humans
- Membrane Glycoproteins
- Molecular Sequence Data
- Neoplasms
- Oligodeoxyribonucleotides
- Phenotype
- RNA, Messenger