Article
Congenic mapping of the MHC-linked susceptibility to type 1 diabetes in the NOD mouse: at least two genes contribute to the Idd16 effect.
Annals of the New York Academy of Sciences - 1 Dec 2008
Hiromine Yoshihisa, Fujisawa Tomomi, Noso Shinsuke, Babaya Naru, Kawabata Yumiko, Ikegami Hiroshi
Abstract excerpt
Major histocompatibility complex (MHC)-linked susceptibility to type 1 diabetes consists of multiple components. Previous studies with NOD mice congenic for the MHC from a sister strain, the CTS mouse, mapped Idd16, a second component of MHC-linked susceptibility to type 1 diabetes, in the region adjacent to, but distinct from Idd1 in the class II region. In this study, three lines of subcongenic strains were...
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