Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Congenic mapping of the MHC-linked susceptibility to type 1 diabetes in the NOD mouse: at least two genes contribute to the Idd16 effect.

Annals of the New York Academy of Sciences - 1 Dec 2008

Hiromine Yoshihisa, Fujisawa Tomomi, Noso Shinsuke, Babaya Naru, Kawabata Yumiko, Ikegami Hiroshi

Abstract excerpt

Major histocompatibility complex (MHC)-linked susceptibility to type 1 diabetes consists of multiple components. Previous studies with NOD mice congenic for the MHC from a sister strain, the CTS mouse, mapped Idd16, a second component of MHC-linked susceptibility to type 1 diabetes, in the region adjacent to, but distinct from Idd1 in the class II region. In this study, three lines of subcongenic strains were...

Topics

Animals
Chromosome Mapping
Chromosomes
Diabetes Mellitus, Type 1
Epistasis, Genetic
Female
Genes
Genes, MHC Class II
Genetic Predisposition to Disease
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Congenic

Mice, Inbred NOD

Source

Identifiers

PMID: 19120274
DOI: 10.1196/annals.1447.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Congenic mapping of the MHC-linked susceptibility to type 1 diabetes in the NOD mouse: at least two genes contribute to the Idd16 effect.PMID 19120274Read ↗

MHC-linked susceptibility to type 1 diabetes in the NOD mouse: further localization of Idd16 by subcongenic analysis.Semantic proximity Read ↗

Congenic mapping and candidate sequencing of susceptibility genes for Type 1 diabetes in the NOD mouse.Semantic proximity Read ↗

Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

The idd4 locus displays sex-specific epistatic effects on type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci.Semantic proximity Read ↗

Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse.Semantic proximity Read ↗

Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits.Semantic proximity Read ↗

Localization of Idd11 is not associated with thymus and nkt cell abnormalities in NOD mice.Semantic proximity Read ↗

Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice.Semantic proximity Read ↗

Localization of Idd11 using NOD congenic mouse strains: elimination of Slc9a1 as a candidate gene.Semantic proximity Read ↗

Allelic variation in class I K gene as candidate for a second component of MHC-linked susceptibility to type 1 diabetes in non-obese diabetic mice.Semantic proximity Read ↗

A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.