Article
Contribution of class III MHC to susceptibility to type 1 diabetes in the NOD mouse.
Annals of the New York Academy of Sciences - 1 Oct 2006
Yamaji Kaori, Ikegami Hiroshi, Fujisawa Tomomi, Noso Shinsuke, Nojima Koji, Babaya Naru, Itoi-Babaya Michiko, Kobayashi Misato, Hiromine Yoshihisa, Makino Susumu, Ogihara Toshio
Abstract excerpt
A recombinant major histocompatibility complex (MHC) with the same class III region as the NOD mouse, but different class II region from the NOD mouse was identified in the NON mouse, and NOD mice congenic for this recombinant MHC, NOD.NON-H2, was established. None of the congenic mice homozygous for the NON MHC developed type 1 diabetes, indicating that the NOD MHC is necessary for the development of type 1...
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