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Article

Lithocholic acid-sensitive mutant cells isolated from Chinese hamster ovary cells are cross-sensitive to cytoskeleton-disturbing agents.

Toxicology letters - 1 Mar 1993

Kaneko M, Kodama M, Inoue F, Horikoshi J

Abstract excerpt

The lithocholic acid-sensitive mutant cells were isolated from CHO-9 cells mutagenized with ethylmethane sulfonate, through clonal selection on 96-well dishes. The isolated mutant cells (LSJ-11) were 3-fold more sensitive than controls in the survival to lithocholic acid and were also sensitive to other bile acids such as deoxycholic acid and cholic acid. As a preliminary characterization, it was found that the...

Topics

Animals
CHO Cells
Cell Survival
Colchicine
Colony-Forming Units Assay
Cricetinae
Cytochalasin B
Cytoskeleton
Demecolcine
Dose-Response Relationship, Drug
Ethyl Methanesulfonate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lithocholic Acid

Mutagenesis

Mutation

Paclitaxel

Source

Identifiers

PMID: 8097340
DOI: 10.1016/0378-4274(93)90001-e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8097340-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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