Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cross-resistance and biochemical characteristics of second-step mutants of HeLa cells resistant to cardiac glycosides.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 May 1990

Chopra A, Dudani A K, Gupta R S

Abstract excerpt

From ouabain-resistant (OuaR) mutants of HeLa cells which do not show any cross resistance to the digoxin analog SC4453, stable second-step mutants resistant to either SC4453 or those exhibiting increased resistance to digoxin have been isolated. The mutants obtained exhibited highly specific cross resistance towards different cardiac glycosides (CGs) and, based on their cross-resistance patterns, contained more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Cricetinae
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Amplification

Share to HeLa Cells

Share to Mutation

Share to Nucleic Acid Hybridization

Share to Transcription, Genetic

Source

Identifiers

PMID: 2169261
DOI: 10.1139/o90-126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cross-resistance and biochemical characteristics of second-step mutants of HeLa cells resistant to cardiac glycosides.PMID 2169261Read ↗

Identification of an amino acid substitution in human alpha 1 Na,K-ATPase which confers differentially reduced affinity for two related cardiac glycosides.Semantic proximity Read ↗

Ouabain-resistant (Na+,K+)-ATPase enzyme activity in chemically induced ouabain-resistant C3H/10T1/2 cells.Semantic proximity Read ↗

Cross-resistance between cisplatin, antimony potassium tartrate, and arsenite in human tumor cells.Semantic proximity Read ↗

Tolerance to O6-methylguanine and 6-thioguanine cytotoxic effects: a cross-resistant phenotype in N-methylnitrosourea-resistant Chinese hamster ovary cells.Semantic proximity Read ↗

Characterization of auromomycin-resistant hamster cell mutants that display a multidrug resistance phenotype.Semantic proximity Read ↗

Cross-resistance to heavy metals in hydrogen peroxide-resistant CHO cell variants.Semantic proximity Read ↗

Unstable expression of the multi-drug-resistant phenotype in Chinese hamster ovary cells resistant to okadaic acid.Semantic proximity Read ↗

Menadione-resistant Chinese hamster cell variants are cross-resistant to hydrogen peroxide and exhibit stable chromosomal and biochemical alterations.Semantic proximity Read ↗

Modulation of pump function by mutations in the first transmembrane region of Na(+)-K(+)-ATPase alpha 1-subunit.Semantic proximity Read ↗

Chinese hamster ovary cells resistant to okadaic acid express a multidrug resistant phenotype.Semantic proximity Read ↗

Gamma-ray- and UV-sensitive strains of a radioresistant cell line: isolation and cross-sensitivity to other agents.Semantic proximity Read ↗

Lithocholic acid-sensitive mutant cells isolated from Chinese hamster ovary cells are cross-sensitive to cytoskeleton-disturbing agents.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.