Article
Cross-resistance and biochemical characteristics of second-step mutants of HeLa cells resistant to cardiac glycosides.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 May 1990
Chopra A, Dudani A K, Gupta R S
Abstract excerpt
From ouabain-resistant (OuaR) mutants of HeLa cells which do not show any cross resistance to the digoxin analog SC4453, stable second-step mutants resistant to either SC4453 or those exhibiting increased resistance to digoxin have been isolated. The mutants obtained exhibited highly specific cro...
Topics
- Animals
- Cardiac Glycosides
- Cell Line
- Cricetinae
- Digoxin
- Drug Resistance
- Gene Amplification
- HeLa Cells
- Humans
- Mutation
- Nucleic Acid Hybridization
- Ouabain
- Rubidium Radioisotopes
- Sodium-Potassium-Exchanging ATPase
- Transcription, Genetic