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Article

Isolation of a fibroblast mutant resistant to Clostridium difficile toxins A and B.

Microbial pathogenesis - 1 Nov 1991

Florin I

Abstract excerpt

A mutant of Chinese hamster lung fibroblasts (Don cells), resistant against Clostridium difficile toxins A and B, was isolated after mutagenization with ethylmethanesulphonate and a two-step selection with toxin B. The mutant, termed CdtR-Q, was 10(4) times more resistant to toxin B than wild-type cells and cross-resistant to toxin A (10(3) times more resistant). The resistance was overcome by increasing the dose...

Topics

Animals
Bacterial Proteins
Bacterial Toxins
Cell Membrane
Cells, Cultured
Clostridioides difficile
Cricetinae
Cricetulus
Dose-Response Relationship, Drug
Enterotoxins
Fibroblasts
Hemolysin Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phospholipases

Source

Identifiers

PMID: 1816487
DOI: 10.1016/0882-4010(91)90019-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1816487-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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