Article
Isolation and characterization of nitrogen mustard-sensitive mutants of Chinese hamster ovary cells.
Mutation research - 1 Mar 1991
Meyn R E, Murray D, vanAnkeren S C, Bernard G S, Mellard D N, Hobbs M L
Abstract excerpt
Three nitrogen mustard-sensitive lines of Chinese hamster ovary cells were isolated from mutagenized cultures using the procedure of Thompson et al. (1980). The lines, designated NM1, NM2 and NM3, were 2.1-, 17- and 6.8-fold more sensitive to nitrogen mustard, respectively, than their parent, wild-type, line as determined by the dose required to kill 90% of the cells, IC90. Patterns of cross-sensitivity to other...
Topics
- Aminacrine
- Animals
- Cells, Cultured
- Cisplatin
- Cricetinae
- Cross Reactions
- DNA
- Dose-Response Relationship, Drug
- Female
- Gamma Rays
- In Vitro Techniques
- Mechlorethamine