Phenotype reversal in induced mutants of CHO cells: analysis of the reversed cell lines.

doi:10.1016/0027-5107(91)90140-j

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Article

Phenotype reversal in induced mutants of CHO cells: analysis of the reversed cell lines.

Mutation research - 1 Jul 1991

Ouellette G, Bradley W E

Abstract excerpt

We have previously shown that descendants of CHO-derived hprt or aprt mutants induced by ethyl methanesulphonate usually undergo a rapid loss of the mutant phenotype during the 10 generations or so of culture in non-selective medium immediately following mutagenesis (Bradley, 1980; Bradley and La...

Topics

Adenine Phosphoribosyltransferase
Animals
Blotting, Northern
Cell Line
Cricetinae
Cricetulus
DNA
DNA Probes
Ethyl Methanesulfonate
Hybrid Cells
Hypoxanthine Phosphoribosyltransferase
Karyotyping
Mutagens
Mutation
Phenotype
RNA, Messenger

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