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Article

Isolation and characterization of Chinese hamster ovary cell mutants defective in intracellular low density lipoprotein-cholesterol trafficking.

The Journal of cell biology - 1 Feb 1990

Cadigan K M, Spillane D M, Chang T Y

Abstract excerpt

This paper reports the isolation and characterization of Chinese hamster ovary cell mutants defective in low density lipoprotein (LDL)-cholesterol trafficking. The parental cell line was 25-RA, which possesses LDL receptors and various cholesterogenic enzyme activities that are partially resistant to down regulation by exogenous sterols (Chang, T. Y., and J. S. Limanek. 1980. J. Biol. Chem. 255:7787-7795)....

Topics

Animals
Cell Line
Cell Separation
Cholesterol Esters
Cholesterol, LDL
Cricetinae
Cricetulus
Female
Fluorescent Antibody Technique
Hybrid Cells
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovary

Phenotype

Receptors, LDL

Sterols

Source

Open in PubMed Open full text

Identifiers

PMID: 2404988
DOI: 10.1083/jcb.110.2.295
PMCID: PMC2116012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2404988-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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