Somatic cell genetic analysis of two classes of CHO cell mutants expressing opposite phenotypes in sterol-dependent regulation of cholesterol metabolism.

doi:10.1007/BF02255839

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Article

Somatic cell genetic analysis of two classes of CHO cell mutants expressing opposite phenotypes in sterol-dependent regulation of cholesterol metabolism.

Somatic cell and molecular genetics - 1 Nov 1994

Hasan M T, Chang T Y

Abstract excerpt

Two different classes of hamster cell mutants (25RA cells and M1 cells) express opposite phenotypes in sterol dependent regulation. In 25RA cells, sterols added in growth medium fail to cause down-regulation of sterol synthesis rate and low density lipoprotein (LDL) receptor activity, while in M1...

Topics

Animals
CHO Cells
Cholesterol
Cricetinae
Genes, Dominant
Genetic Complementation Test
Hybrid Cells
Models, Genetic
Mutation
Receptors, LDL
Sterols
Transfection
Up-Regulation

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