Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic cell genetic analysis of two classes of CHO cell mutants expressing opposite phenotypes in sterol-dependent regulation of cholesterol metabolism.

Somatic cell and molecular genetics - 1 Nov 1994

Hasan M T, Chang T Y

Abstract excerpt

Two different classes of hamster cell mutants (25RA cells and M1 cells) express opposite phenotypes in sterol dependent regulation. In 25RA cells, sterols added in growth medium fail to cause down-regulation of sterol synthesis rate and low density lipoprotein (LDL) receptor activity, while in M1 cells, removal of lipids from growth medium fail to cause up-regulation of sterol synthesis rate and LDL receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Cholesterol
Share to Cricetinae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Genetic Complementation Test

Share to Models, Genetic

Share to Mutation

Share to Transfection

Source

Identifiers

PMID: 7892647
DOI: 10.1007/BF02255839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic cell genetic analysis of two classes of CHO cell mutants expressing opposite phenotypes in sterol-dependent regulation of cholesterol metabolism.PMID 7892647Read ↗

Somatic cell genetic and biochemical characterization of cell lines resulting from human genomic DNA transfections of Chinese hamster ovary cell mutants defective in sterol-dependent activation of sterol synthesis and LDL receptor expression.Semantic proximity Read ↗

Isolation and characterization of Chinese hamster ovary cell mutants defective in intracellular low density lipoprotein-cholesterol trafficking.Semantic proximity Read ↗

Chinese hamster ovary cell mutants affecting cholesterol metabolism.Semantic proximity Read ↗

Isolation of NPC1-deficient Chinese hamster ovary cell mutants by gene trap mutagenesis.Semantic proximity Read ↗

A 25-hydroxycholesterol-resistant cell line deficient in acyl-CoA: cholesterol acyltransferase.Semantic proximity Read ↗

Silencing of the mutant SCAP allele accounts for restoration of a normal phenotype in CT60 cells selected for NPC1 expression.Semantic proximity Read ↗

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Semantic proximity Read ↗

Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1.Semantic proximity Read ↗

Isolation and characterization of Chinese hamster ovary cell mutants defective in glucose transport.Semantic proximity Read ↗

Phenotype reversal in induced mutants of CHO cells: analysis of the reversed cell lines.Semantic proximity Read ↗

A rapid selection for animal cell mutants with defective peroxisomes.Semantic proximity Read ↗

Chinese hamster ovary cells with reduced hexokinase activity maintain normal GDP-mannose levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.