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Article

Streptozotocin-induced chromosomal aberrations, SCEs and mutations in CHO-9 parental cells and in EM-C11 mutant cell line.

Mutation research - 1 Feb 1995

Capucci M S, Hoffmann M E, Zdzienicka M Z, Natarajan A T

Abstract excerpt

The genotoxic effects induced by the monofunctional nitrosourea derivative streptozotocin (STZ) were investigated in Chinese hamster ovary cells, parental (CHO-9) and its mutant hypersensitive to alkylating agents, designated EM-C11. The ability of this compound to induce chromosomal aberrations, cell killing, sister-chromatid exchanges (SCEs) and mutations was evaluated on these two cell lines. The mutant cells...

Topics

Animals
CHO Cells
Cell Line
Cell Survival
Chromosome Aberrations
Cricetinae
Cricetulus
DNA Repair
Dose-Response Relationship, Drug
Hypoxanthine Phosphoribosyltransferase
Mutagenicity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagens

Mutation

Sister Chromatid Exchange

Sodium-Potassium-Exchanging ATPase

Streptozocin

Source

Identifiers

PMID: 7529888
DOI: 10.1016/0027-5107(94)00172-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7529888-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Streptozotocin-induced chromosomal aberrations, SCEs and mutations in CHO-9 parental cells and in EM-C11 mutant cell line.PMID 7529888Read ↗

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