Article
Consortium study on 1280 breast carcinomas: allelic loss on chromosome 17 targets subregions associated with family history and clinical parameters.
Cancer research - 1 Mar 1998
Phelan C M, Borg A, Cuny M, Crichton D N, Baldersson T, Andersen T I, Caligo M A, Lidereau R, Lindblom A, Seitz S, Kelsell D, Hamann U, Rio P, Thorlacius S, Papp J, Olah E, Ponder B, Bignon Y J, Scherneck S, Barkardottir R, Borresen-Dale A L, Eyfjörd J, Theillet C, Thompson A M, Larsson C
Abstract excerpt
The pattern of loss of heterozygosity (LOH) on chromosome 17 in human breast cancer is complicated and shows many different regions of loss. In an attempt to narrow down the relevant regions of LOH on chromosome 17, we have studied the deletion pattern and its association with clinical parameters...
Topics
- Adult
- Alleles
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- Female
- Genes, Tumor Suppressor
- Genetic Markers
- Humans
- Loss of Heterozygosity
- Middle Aged