Article
Mutation analysis of the BRCA1 gene in ovarian cancers.
Cancer research - 15 Jul 1995
Takahashi H, Behbakht K, McGovern P E, Chiu H C, Couch F J, Weber B L, Friedman L S, King M C, Furusato M, LiVolsi V A
Abstract excerpt
Germline mutations of the BRCA1 tumor suppressor gene on chromosome 17q are involved in a significant fraction of hereditary breast and ovarian cancers. Allelic deletions that include the BRCA1 locus are common in breast and ovarian cancers, implying that somatic mutations of this gene may play an important role in the more common sporadic forms of these tumors as well. The recent cloning of BRCA1 allows direct...
Topics
- Adult
- Aged
- Alleles
- BRCA1 Protein
- Base Sequence
- Breast Neoplasms
- DNA Mutational Analysis
- DNA, Neoplasm
- Exons
- Female
- Frameshift Mutation
- Gene Deletion