Article
Molecular heterogeneity of the XbaI defined 44kb allele of the CYP2D locus within the Caucasian population.
British journal of clinical pharmacology - 1 Feb 1993
Mura C, Gerard N, Vincent-Viry M, Galteau M M, Jacqz-Aigrain E, Krishnamoorthy R
Abstract excerpt
1. Cytochrome P450 debrisoquine (CYP2D6) activity is polymorphic and under genetic control. Most Caucasians are extensive metabolizers, but 5%-10% are poor metabolizers. 2. Restriction fragment length polymorphism analysis of the CYP2D6 locus identifies a 29kb XbaI fragment, either normal (D6-wt) or mutated, and three mutated XbaI alleles (44kb, 11.5kb and 16 + 9kb). The 44kb allele was initially considered as a...
Topics
- Alleles
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Deoxyribonucleases, Type II Site-Specific
- Female
- France
- Genotype
- Humans
- Male
- Mixed Function Oxygenases
- Molecular Weight