Article
Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.
American journal of human genetics - 1 May 1991
Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, Meyer U A
Abstract excerpt
The debrisoquine/sparteine polymorphism is associated with a clinically important genetic deficiency of oxidative drug metabolism. From 5% to 10% of Caucasians designated as poor metabolizers (PMs) of the debrisoquine/sparteine polymorphism have a severely impaired capacity to metabolize more than 25 therapeutically used drugs. The impaired drug metabolism in PMs is due to the absence of cytochrome P450IID6...
Topics
- Base Sequence
- Chromosome Deletion
- Chromosomes, Human, Pair 22
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Homozygote
- Humans
- Molecular Sequence Data
- Oxidation-Reduction
- Phenotype