Xbal 16- plus 9-kilobase DNA restriction fragments identify a mutant allele for debrisoquin hydroxylase: report of a family study.

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Article

Xbal 16- plus 9-kilobase DNA restriction fragments identify a mutant allele for debrisoquin hydroxylase: report of a family study.

Molecular pharmacology - 1 May 1990

Evans W E, Relling M V

Abstract excerpt

Previous studies have established that two Xbal polymorphic restriction fragments [11.5 and 44 kilobases (kb)] hydridizing to a full length debrisoquin hydroxylase cDNA are associated with two different mutant alleles for the debrisoquin hydroxylase gene (IID6). An independent allele, defined by Xbal 16- and 9-kb fragments, has previously been identified only in extensive metabolizers, precluding determination of...

Topics

Adult
Alleles
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
DNA
Deoxyribonucleases, Type II Site-Specific
Female
Genes
Genetic Carrier Screening
Humans
Leukocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mixed Function Oxygenases

Molecular Weight

Mutation

Pedigree

Phenotype

Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 1971090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1971090-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Xbal 16- plus 9-kilobase DNA restriction fragments identify a mutant allele for debrisoquin hydroxylase: report of a family study.PMID 1971090Read ↗

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