Article
DNA haplotype dependency of debrisoquine 4-hydroxylase (CYP2D6) expression among extensive metabolisers.
Human genetics - 1 Oct 1993
Mura C, Panserat S, Vincent-Viry M, Galteau M M, Jacqz-Aigrain E, Krishnamoorthy R
Abstract excerpt
Deficient debrisoquine/sparteine type oxidation is inherited as an autosomal recessive trait. Of all Caucasians, 5-10% are poor metabolisers, due to the absence of cytochrome P4502D6. Extensive metabolisers (EMs) exhibit highly variable metabolic activity. We investigated the relationship between...
Topics
- Adolescent
- Adult
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- DNA
- DNA Mutational Analysis
- Debrisoquin
- Dextromethorphan
- Female
- Gene Expression Regulation, Enzymologic
- Genotype
- Haplotypes
- Humans
- Male
- Mixed Function Oxygenases
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Genetic