Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population.

doi:10.1038/clpt.1992.2

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Article

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population.

Clinical pharmacology and therapeutics - 1 Jan 1992

Dahl M L, Johansson I, Palmertz M P, Ingelman-Sundberg M, Sjöqvist F

Abstract excerpt

The molecular basis of polymorphic debrisoquin hydroxylation was studied in 223 Swedish white subjects, 187 extensive metabolizers and 36 poor metabolizers phenotyped with debrisoquin and desipramine. Restriction fragment length polymorphism (RFLP) analysis of the CYP2D6 gene revealed that 52% of...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Child
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
DNA
Debrisoquin
Deoxyribonucleases, Type II Site-Specific
Desipramine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Amplification

Humans

Hydroxylation

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 1346258
DOI: 10.1038/clpt.1992.2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1346258-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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