Article
Evolutionary pharmacogenetics of CYP2D6 in Ngawbe Guaymi of Panama: allele-specific PCR detection of the CYP2D6B allele and RFLP analysis.
Pharmacogenetics - 1 Oct 1993
Jorge L F, Arias T D, Griese U, Nebert D W, Eichelbaum M
Abstract excerpt
Gene cluster CYP2D controls the biosynthesis of enzyme CYP2D6, which is responsible for the polymorphic oxidation of sparteine, debrisoquine and related drugs. This cluster consists of the functional gene D6 and of two pseudogenes, D7 and D8. RFLP Bam HI analysis of CYP2D in 37 unrelated and eigh...
Topics
- Alleles
- Biological Evolution
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Female
- Gene Frequency
- Genotype
- Humans
- Indians, Central American
- Male
- Mixed Function Oxygenases
- Multigene Family
- Panama
- Phenotype
- Polymorphism, Restriction Fragment Length
- Pseudogenes