Article
DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): evidence for two major allozymes in extensive metabolisers.
Human genetics - 1 Oct 1994
Panserat S, Mura C, Gérard N, Vincent-Viry M, Galteau M M, Jacqz-Aigrain E, Krishnamoorthy R
Abstract excerpt
The molecular basis for DNA haplotype-dependent debrisoquine 4-hydroxylase (CYP2D6) expression was explored by sequencing all of the nine exons of the CYP2D6 gene. Two distinct exon sequence frameworks of the CYP2D6 gene were found, each associated with specific BamHI-defined DNA haplotypes of th...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- DNA
- DNA Primers
- Exons
- Haplotypes
- Humans
- Isoenzymes
- Mixed Function Oxygenases
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic