Article
DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): evidence for two major allozymes in extensive metabolisers.
Human genetics - 1 Oct 1994
Panserat S, Mura C, Gérard N, Vincent-Viry M, Galteau M M, Jacqz-Aigrain E, Krishnamoorthy R
Abstract excerpt
The molecular basis for DNA haplotype-dependent debrisoquine 4-hydroxylase (CYP2D6) expression was explored by sequencing all of the nine exons of the CYP2D6 gene. Two distinct exon sequence frameworks of the CYP2D6 gene were found, each associated with specific BamHI-defined DNA haplotypes of the CYP2D cluster. They corresponded to Arg296/Cys296 and Ser486/Thr486 amino acid polymorphisms in the CYP2D6 enzyme,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.