Article
Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology.
Pharmacogenetics - 1 Aug 1995
Steen V M, Andreassen O A, Daly A K, Tefre T, Børresen A L, Idle J R, Gulbrandsen A K
Abstract excerpt
The cytochrome P450 enzyme debrisoquine 4-hydroxylase metabolizes many different classes of commonly used drugs, such as antidepressants and neuroleptics. Deficient hydroxylation of debrisoquine, known as the poor metabolizer (PM) phenotype, affects 5-10% of Caucasians and may lead to adverse reactions upon administration of drugs in standard doses. This autosomal recessive metabolic deficiency is caused by the...
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