Article
Loss of p53 in esophageal squamous cell carcinoma and the correlation with survival: analyses of gene mutations, protein expression, and loss of heterozygosity in Japanese patients.
Journal of surgical oncology - 1 Aug 2011
Egashira Akinori, Morita Masaru, Yoshida Rintaro, Saeki Hiroshi, Oki Eiji, Sadanaga Noriaki, Kakeji Yoshihiro, Tsujitani Shun-Ichi, Maehara Yoshihiko
Abstract excerpt
BACKGROUND: A high frequency of p53 protein expression or gene mutation has been reported in the early stages of esophageal squamous cell carcinoma (ESCC), and thus loss of p53 function is thought to be very important in esophageal carcinogenesis. However, there is controversy surrounding the correlation between p53 dysfunction and ESCC tumor progression. The complexity arises from the different modalities, such...
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