Detection of 17p loss in gastric carcinoma using polymerase chain reaction.

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Article

Detection of 17p loss in gastric carcinoma using polymerase chain reaction.

Laboratory investigation; a journal of technical methods and pathology - 1 Feb 1995

Kim C J, Kim W H, Kim C W, Lee J B, Lee C K, Kim Y L

Abstract excerpt

BACKGROUND: The loss of heterozygosity (LOH) of 17p has been previously studied with conventional Southern blot-restriction fragment length polymorphism analysis, but the relatively low informativity was an obstacle to extensive analysis. To overcome this problem and to investigate the significance of 17p LOH in gastric carcinoma, we employed polymerase chain reaction and subsequent silver staining of DNA....

Topics

Adult
Aged
Alleles
Base Sequence
Blotting, Southern
Carcinoma
Chromosome Deletion
DNA Primers
DNA, Neoplasm
Female
Gene Deletion
Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Immunohistochemistry

Male

Middle Aged

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7853854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7853854-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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