Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of p53 mutations in hematological malignancies: comparison between immunocytochemistry and DNA analysis.

Leukemia - 1 Aug 1994

Lepelley P, Preudhomme C, Vanrumbeke M, Quesnel B, Cosson A, Fenaux P

Abstract excerpt

The wild type p53 protein has a short half-life and cannot be detected by immunohistochemistry on tissue sections. Mutated p53, on the other hand, has a prolonged half-life and becomes detectable by this method, so that its detection by immunohistochemistry in solid tumors is almost synonymous with mutation. We assessed the value of immunocytochemical analysis of p53 protein on blood or bone marrow slides in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Blotting, Southern
Share to DNA Primers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 8057671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of p53 mutations in hematological malignancies: comparison between immunocytochemistry and DNA analysis.PMID 8057671Read ↗

Correlation between mutation in P53, p53 expression, cytogenetics, histologic type, and survival in patients with B-cell non-Hodgkin's lymphoma.Semantic proximity Read ↗

Detection of serum anti p53 antibodies and their correlation with p53 mutations in myelodysplastic syndromes and acute myeloid leukemia.Semantic proximity Read ↗

Detection of p53 gene mutations in human leukemia by PCR-SSCP analysis and direct nucleotide sequencing.Semantic proximity Read ↗

p53 protein expression in non-Hodgkin's lymphomas is infrequently related to p53 gene mutations.Semantic proximity Read ↗

Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood.Semantic proximity Read ↗

Detection of p53 mutations using nonradioactive SSCP analysis: p53 is not frequently mutated in myelodysplastic syndromes (MDS).Semantic proximity Read ↗

Prognostic value of p53 gene mutations and the product expression in de novo acute myeloid leukemia.Semantic proximity Read ↗

Correlation between mutations in p53 gene and protein expression in human lymphomas.Semantic proximity Read ↗

The immunocytochemical detection of p53 protein in cytological specimens: technical considerations.Semantic proximity Read ↗

Detection of p53 gene mutations in fine-needle aspiration biopsied breast cancer specimens: correlations with nuclear p53 accumulations and tumor DNA aneuploidy patterns.Semantic proximity Read ↗

Mutations of the p53 tumour suppressor gene in haematologic neoplasms.Semantic proximity Read ↗

A comparative study of detection of p53 mutations in human breast cancer by flow cytometry, single-strand conformation polymorphism and genomic sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.