Article
Detection of p53 mutations in hematological malignancies: comparison between immunocytochemistry and DNA analysis.
Leukemia - 1 Aug 1994
Lepelley P, Preudhomme C, Vanrumbeke M, Quesnel B, Cosson A, Fenaux P
Abstract excerpt
The wild type p53 protein has a short half-life and cannot be detected by immunohistochemistry on tissue sections. Mutated p53, on the other hand, has a prolonged half-life and becomes detectable by this method, so that its detection by immunohistochemistry in solid tumors is almost synonymous wi...
Topics
- Anemia
- Base Sequence
- Blast Crisis
- Blotting, Southern
- Bone Marrow
- DNA Primers
- Exons
- Genes, p53
- Humans
- Immunohistochemistry
- Leukemia
- Leukemia, Myeloid, Acute
- Molecular Sequence Data
- Mutation
- Myelodysplastic Syndromes
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Precursor Cell Lymphoblastic Leukemia-Lymphoma