Article
Mutations in the p53 gene in acute myeloid leukemia patients correlate with poor prognosis.
Hematology (Amsterdam, Netherlands) - 1 Feb 2002
Melo Mônica B, Ahmad Nilofer N, Lima Carmen S P, Pagnano Katia B B, Bordin Silvana, Lorand-Metze Irene, SaAd Sara T O, Costa Fernando F
Abstract excerpt
Inactivation of tumor suppressor genes, whose products exert an inhibitory influence on cell cycle progression, can lead to neoplastic transformation. In acute myeloid leukemia (AML), the frequency of p53 gene mutations ranges from 4 to 15% in populations from USA and Europe. In an attempt to investigate the frequency of point mutations in the p53 gene in AML Brazilian patients, DNA samples of 35 patients were...
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