Article
Activation of the cryptic DNA binding function of mutant forms of p53.
Nucleic acids research - 11 Jul 1993
Hupp T R, Meek D W, Midgley C A, Lane D P
Abstract excerpt
Wild type p53 assembles into a latent multiprotein complex which can be activated for sequence-specific DNA binding in vitro by proteins targeting the carboxy-terminal domain. Using an optimized system coupling the post-translational modification of wild type p53 to activation of sequence specific DNA binding, we examined the affects of common mutations on the cryptic DNA binding function of p53. Two mutant forms...
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